Genetic factors are equally noteworthy: recessive TMEM167A variants can directly cause neonatal diabetes mellitus, microcephaly, and epilepsy syndrome (93), while epilepsy and T1DM share four potential pathogenic factors: genetic predisposition, factors involved in autoimmune responses, dysglycemia, and ischaemic processes caused by cerebrovascular damage (94)
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Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]
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