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It was the worlds first PEGylated long-acting GLP-1RA

In addition to GIP and glucagon, GLP1 has also been implicated to interact with other hormones involved in metabolism

Accounting for discontinuation, cumulative GLP-1 spending is about $6,500 in the first year and $22,500 over five years

There is much interest in its clinical application in various neural disorders such as Alzheimer's disease and painful neuropathies [114]

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"Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist." JCI Insight , 5(17), e140532