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How should clinicians apply opioid prescribing guidelines when treating acute pain

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Journal of Clinical Investigation, March 2025

The dose can be increased to 1 mg or 2 mg weekly if needed for improved glycaemic control

The same oxidative stress pathways are involved in PANS, mood disorders, and other psychiatric conditions, suggesting a unifying biology of inflammation and mental health

And crucially, women need to take folic acid up to five milligrams for at least one to three months prior to conception, because you remember the increased neural tube defects twofold over and above women with a normal BMI