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These adjustments are based on a balance between results and tolerability

This rate may be even faster as we age, especially after the age of 60 years

Pancreatitis and Pancreatic Cancer Large clinical trials have not shown an increased risk of pancreatitis or pancreatic cancer with GLP-1 medications compared to placebo

The limitations include the relatively small sample size of the MASLD substudy, the geographic and racial homogeneity of the sample (United States only and majority white), the exclusion of patients with T2D, the absence of liver histology, the lack of enrichment for MASH or significant fibrosis, the lack of multiplicity control given the large number of statistical assessments and the absence of 48-week MRI data for 56.1% of participants, which limits interpretation of the dose-response relationship for liver fat reduction at 48 weeks

The hormone also slows down gastric emptying and digestion, which helps us feel physically fuller for longer periods of time. Delayed stomach emptying also prevents blood glucose spikes, per the Cleveland Clinic

Bramante, thanks for joining us here on Minnesota Now