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Mood changes, including depression or irritability, can also be related to low B12 levels

WEIGHT-LOSS DRUGS' IMPACT ON CANCER RISK REVEALED IN NEW STUDY The National Institutes of Health (NIH) published research in June 2024 that considered the correlation between semaglutide therapy and "exacerbating mood disturbances." The study highlighted the association of negative mood changes in patients with type 2 diabetes with a history of depression, warning healthcare providers to be aware of this "potential risk." But a more recent study, published in the journal Diabetes, Obesity and Metabolism, suggested that these mood changes were linked to genetic variations across diverse populations and ancestries within the U.K

In animal models of psychosis, liraglutide administration consistently led to a reduction of psychotic-like behavior 119,120,121 , which was also associated with increased brain-derived neurotrophic factor, CREB/p-CREB, and Trk-B expression in the hippocampus and prefrontal cortex 120 , and reduced serum and hippocampal tumor necrosis factor and oxidative stress 121