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Cancer development typically occurs over years to decades

Neurochemical heterogeneity among lateral hypothalamic Hypocretin/Orexin and melanin-concentrating hormone neurons identified through single-cell gene expression analysis

[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Bulboac A.E., Bolboac S.D., Stnescu I.C., Sfrngeu C.A., Bulboac A.C

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To date, no single bacterium, virus, fungus, or fastidious microorganism has been isolated as an etiologic factor in IC/BPS

In addition, obesity has emerged as a key disease modifier affecting patient stratification, trial endpoints, and outcome interpretation