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Importantly, blocking CGRP/RAMP1 signaling using four FDA-approved drugsanti-CGRP antibodies fremanezumab and galcanezumab, and RAMP1 antagonists rimegepant and ubrogepanthas been shown to reduce mechanical hyperalgesia, spontaneous pain, and lesion size in a mouse model of endometriosis

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Sensorgram data were processed and analyzed using the Biacore T200 Evaluation Software (version 3.2.1) with a 1:1 Langmuir binding model to calculate apparent binding affinity (KD) values

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