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In a 26-week Phase 2 obesity trial, cagrilintide 4.5mg produced a mean body-weight reduction of 10.8%, versus 3.0% on placebo and it outperformed liraglutide 3.0mg (10.8% vs 9.0%)[1]

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however, loss of function mutations in HSL cause FLD in humans (142) and partial lipodystrophy with age (204, 205)