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263 In castration-resistant prostate cancer, the UPS supports androgen receptor (AR) function by facilitating its nuclear localization and stabilizing mutated AR proteins, enabling tumor cells to survive and proliferate under low androgen levels

However, the therapeutic efficacy and safety of SM04690 under long-term or repeated dosing remain unverified, and its effects on other joint-resident cells such as synoviocytes and osteoblasts have not been fully explored

Long-term data from the Swedish Obese Subjects study demonstrate sustained weight loss and reduced mortality over 20+ years

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Comprehensive risk factor management, including glucose control, blood pressure optimization, and lifestyle modification, remains the most effective strategy