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HeJLiLYanXLiYWangYHuangJet alSappanone A enhances hepatocyte proliferation in lipopolysaccharide-induced acute liver injury in mice by promoting injured hepatocyte apoptosis and regulating macrophage polarization
In the decomposition reaction of H 2 O 2 or other organic peroxides (HOOR), two molecules of GSH reduce the substrate to H 2 O or the corresponding alcohol (HOR) and restore the enzyme forming GSSG with concomitant formation of GSSG and H 2 O
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Finally, it is worth mentioning the new glutamate-serine-glycine (GSG) index which, combining three amino acids involved in glutathione synthesis, provides a good assessment of NAFLD severity and allows the discrimination of liver fibrosis (64)