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Because some nanoparticles (like chitosan or certain emulsifiers) have antimicrobial properties, they might alter the composition of intestinal flora with long-term use (208, 209)

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Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

Eur Rev Med Pharmacol Sci 20(10):21442150 Saadat S, Naghdi F, Ghorani V, Rakhshandeh H, Boskabady MH (2019) Histamine (H1) receptors, cyclooxygenase pathway and nitric oxide formation involved in rat tracheal smooth muscle relaxant effect of berberine Saha P, Durugkar S, Jain S, Shantanu PA, Panda SR, Jala A, Gokhale S, Sharma P, Naidu VGM (2022) Piperine attenuates cigarette smoke-induced oxidative stress, lung inflammation, and epithelialmesenchymal transition by modulating the SIRT1/Nrf2 axis