Surgical site infection is notably more common in Gliadel-treated patients, with wound dehiscence and delayed healing occurring in approximately 1020% of cases
J Clin Endocrinol Metab 97: 121131
Bacteriostatic preservatives like benzyl alcohol inhibit bacterial growth in multi-dose vials, which is essential for maintaining sterility through repeated needle punctures over weeks of use
Strategies for the oral delivery of peptides are broadly categorized into four methods: (1) permeation enhancers (PEs), (2) nanoparticles, (3) lipid-based drug delivery systems (self-emulsifying drug delivery systems (SEDDS)) or hydrophobic ion-pairing, and (4) microneedle devices
In contrast, slower and more gradual weight loss may help preserve bone density
Injected subcutaneously once a week, it is being developed both as a standalone and possibly also in combination, and has the potential to be a best in class therapy for chronic weight management, type 2 diabetes, and could be expanded to other indications
