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HFD led to astrocyte proliferation, microglial activation, and upregulation of IL-1, IL-6, and TNF- in the hippocampus and cortex, while exenatide treatment significantly reduced these inflammatory markers

My view is that the pronounced effect of GLP-1 analogues on gastric emptying is not only an important mediator of satiety and reduced food intake but also a likely mechanism responsible for its effect on type 2 diabetes and cardiovascular disease

Some clinical trials report that lean mass reductions can account for 40% to 60% of total weight lost, while others show reductions of around 15% or less [45, 46]

Gene array studies reveal that GHK-Cu administration reverses the expression of over 70% of genes that become dysregulated with aging in skin tissue