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The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods

Treatment of diabetic retinopathy according to established clinical guidelines

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The STEP 1 extension study showed approximately two-thirds of weight was regained within one year of stopping semaglutide