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Mechanistic Studies in Neurodegeneration: Further elucidation of GLP-1RAs neuroprotective mechanisms (eg, anti-inflammatory effects, amelioration of cerebral insulin resistance) is warranted, along with evaluation of the neuropsychiatric potential of GLP-1/GIP dual agonists

Retatrutide , a triple receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, is in clinical development

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The FDA classifies these medications as Category C for pregnancy, meaning animal studies have shown potential fetal risk, but human data remains limited

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