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Off-Label Uses of Semaglutide 5.1 Semaglutide for PCOS and Metabolic Regulation 5.2 Non-Alcoholic Fatty Liver Disease (NAFLD/NASH) 5.3 Binge Eating Disorder and Appetite Dysregulation 5.4 Weight Loss in Non-Obese Individuals (Clinical Considerations) 5.5 Cardiovascular Disease Prevention Beyond Approved Scope 5.6 Adjunct in Metabolic Syndrome Management 5.7 Potential Neuroprotective and Anti-Inflammatory Roles (Emerging Research) 6

10.1016/j.ajog.2025.04.069 22 HeydarnejadA.OstadhosseiniS.VarnosfaderaniS

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This suggests that the joint is exposed to circulating GLP-1, but only to a limited extent under physiological conditions