A recent review of the randomised controlled trials literature concluded that while B vitamin supplementation consistently lowers homocysteine, the clinical benefit for thrombosis prevention remains uncertain (5)
The clearest way is a blood test showing low B12 levels, or symptoms like ongoing tiredness, pins and needles, or low mood that havent improved through diet alone
Some sources cite up to 60 days under optimal conditions, but 28 days is the conservative guideline most compounding pharmacies recommend
Smoking Alcohol abuse Having endocrine-related autoimmune disorders (such as diabetes, or thyroid disorder) Gastrointestinal disorders such as Crohns disease Having undergone gastric bypass surgery or other surgeries that remove parts of the stomach
It works by calming inflammatory responses within the body, making it particularly effective for gut health issues like IBD and for reducing skin inflammation associated with conditions like psoriasis
The rat MCL study showed progressive improvement at 14, 30, 45, and 90 days