A phase 2 study (MARIPOSA randomized trial) demonstrated that, in patients with OSA, administration of aroxybutynin (an antimuscarinic agent) combined with atomoxetine (a norepinephrine reuptake inhibitor) led to modest but significant reductions in AHI (AHI reduction of 5.9 events/hour greater than placebo) over a 4-week period, though the use of atomoxetine was also associated with a reduction of total sleep time by approximately 21 min
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Pompili S, Vetuschi A, Latella G, Smakaj A, Sferra R, Cappariello A (2023) PPAR-gamma orchestrates EMT, AGE, and cellular senescence pathways in colonic epithelium and restrains the progression of IBDs
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Until scientists find a specific treatment, coping strategies will play a key role in managing ME/CFS.
L-carnitine is made naturally in the body by the liver and kidneys
