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Goodman clarifies
No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate
Briefly, protein was methanol-precipitated, methanol was evaporated to dryness and subsequent to derivatization samples were injected to an Agilent 7890B-5977B Inert Plus GC-MS system
Its role is especially crucial in the induction of ferroptosis, an iron-dependent cell death pathway, positioning it as a context-dependent modulator of cancer progression, neurotoxicity and neurodegeneration
Hansen JM, Go YM, Jones DP