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Phentermine failures can occur because the appetite suppression was insufficient, because tolerance developed too quickly, or because the patient eating patterns were driven by factors other than hunger (emotional eating, habit, environment)

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J Pharmacol Exp Ther (2011) 339(2):46473.10.1124/jpet.111.184788 24 MargolskeeRFDyerJKokrashviliZSalmonKSIlegemsEDalyKet alT1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1

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