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The flowchart in Figure S1 depicts the disposition of SGLT2i at baseline and during the trial

(2026, January 13)

Understanding the specific effects reported helps set realistic expectations and allows for informed monitoring during treatment protocols

While this research is still early, it may explain why some people develop diarrhea that persists beyond the typical 8 to 12 week adjustment window, and why probiotics have shown anecdotal benefit in managing GLP-1-related GI symptoms

You might feel pressure to reach the maximum dose quickly, but studies show that patients who take 20-24 weeks to reach their optimal dose have better long-term success rates than those who escalate doses rapidly

Were investing in single-serve capacity, he said