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The denial letter will likely state that the medication is not medically necessary for the diagnosed condition (e.g., obesity) or that it's being used for a non-covered service (cosmetic weight loss, in their view)

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retatrutide adds GCGR as a third target

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By virtue of their peptide character, the peptidomimetic inhibitors have poor pharmacokinetics due to susceptibility to metabolic cleavage by peptidases

Almost all patients will have some gastrointestinal side effects during the first week or two of taking the medication, but those symptoms typically resolve over the first two to four weeks and are rarely severe enough to stop therapy