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Brief exposure is sufficient to initiate gene transcription changes that persist for days

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The related Athira compound fosgonimeton failed its Phase 2 Alzheimer's trial (LIFT-AD) in 2023 for efficacy, and Athira discontinued development

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By looking at the gene expression patterns, Li's team first found that the pathway that produces vitamin B12 was significantly altered in the skin bacteria of people with acne, compared with the skin bacteria of people without acne