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Recent evidence demonstrates that stimulation of the TSab on the TSH-R in the orbital fibroblasts can lead to a crosstalk of this receptor with the insulin growth factor 1 receptor (IGF-1R) which stimulates hyaluronan accumulation in the orbital muscles and transformation of orbital fibroblasts into adipocytes (283, 284)

doi: 10.3389/fphys.2018.00044 157

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Clinical and epidemiologic features of psoriasis patients in an Egyptian medical center

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