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Primary candidates include adults with a BMI of 30 kg/m or greater (obesity) or those with a BMI of 27 kg/m or greater (overweight) who have at least one weight-related medical condition such as high blood pressure, type 2 diabetes, or high cholesterol

PubMed Bendich A, Cohen M

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Treated aged mice showed restored coat density, better kidney markers, and improved physical activity

[DOI] [Google Scholar] Katakai R., Kobayashi K., Yamada K., Oku H., Emori N

Current research doesn't provide clear superiority for either approach, and individual preference and logistical convenience should guide timing decisions