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366 Overall, IR is a complex syndrome, which can significantly increase the risk of cardiovascular diseases

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UK National Office of Animal Health Compendium of Animal Medicines

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Despite these limitations, the findings that the effects of oral semaglutide on cardiovascular outcomes were comparable in those with or without baseline or incident SGLT2i are noteworthy, because SOUL is now the GLP-1 RA trial with the highest penetrance of overall concurrent SGLT2i use, and this question remains an important one in clinical practice