weight loss difference between semaglutide and tirzepatide vs What's The Difference between Semaglutide

22.5% at max dose

The review included 47 randomized controlled studies with over 23,000 participants with overweight or obesity, some of whom also had diabetes

Retatrutide (LY3437943) is an investigational once-weekly injectable peptide developed by Eli Lilly that activates three key metabolic pathways simultaneously

You can read the abstract at Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial Among people who are overweight or obese, it is well established that weight loss can reduce cardiometabolic risk factors

This can lead to reduced expression of GLP- 1 receptors and the development of GLP- 1 resistance

You should contact a doctor or go to A&E straight away if you get this side effect