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28.0 kg/m 2 , P 6 months in validation cohorts, but not in the discovery cohort

If it persists, a psyllium-based supplement may be worth discussing with your provider

Activation of GIP could protect bone density Rapid, substantial weight loss reduces the static and dynamic loads on the skeleton, causing the body to increase bone resorption and decrease bone formation, leading to a decline in bone mineral density (BMD)

Surgical options like gastric bypass or sleeve gastrectomy enhance metabolic function, promote sustained weight loss, and resolve conditions like Type 2 diabetes without the ongoing challenge of medication management

This stepwise approach significantly reduces gastrointestinal side effects

Best Clinics for Affordable GLP-1s in 2026 Editors Note (April 2026) This article has been updated with new clinic rankings and fresh provider information