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The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Informed consent was obtained from all study participants

Excess adipose tissue, particularly visceral fat, promotes a pro-inflammatory state and endothelial dysfunction, impairing the nitric oxide-mediated vasodilation essential for erectile function

Drug Targets 7 , 14351441 (2006)

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Approximately 0.1% of all oxygen entering the mitochondrial electron transport chain is released as ROS, which can disrupt intracellular redox status and result in homeostasis disorder (Zhang et al., 2008