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However, our understanding of subcellular NAD(P) redox dynamics is still remarkably incomplete, mainly due to a deficit of techniques allowing specific monitoring in defined subcellular compartments in vivo
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The statistical testing strategy for the confirmatory secondary end points used a separate alpha spending function to control type I error rate at a 1-sided level of 2.5%, which aligned with the P value adjustment for the group sequential design
Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility A 104-week carcinogenicity study was conducted in male and female CD-1 mice at doses of 0.03, 0.2, 1, and 3 mg/kg/day liraglutide administered by bolus subcutaneous injection yielding systemic exposures 0.2-, 2-, 10- and 43-times the exposure in obese humans, respectively, at the maximum recommended human dose (MRHD) of 3 mg/day based on plasma AUC comparison