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In vitro and in vivo activity of sEV-semaglutide and sEV-tirzepatide To investigate the in vitro and in vivo activity of sEV-semaglutide or sEV-tirzepatide, we utilized an in vitro cell assay (293 cell line that expresses both the hGLP-1R and CRE firefly luciferase) and an in vivo mouse model (db/db diabetic mice) 36

The standard course is two injections of 12 mg each, 24 hours apart (total 24 mg) (Cochrane) Maximum benefit is about 24 to 48 hours after the first dose

Treatment requires a medical evaluation and lab review prior to starting

Further evidence from Al-Amin et al

Semaglutide, either alone or combined with papaya, effectively modulated these apoptotic markers by downregulating Bax and caspase-3 while upregulating Bcl-2

T2DM: distinct pathophysiological profiles While T1DM and T2DM share core mechanisms, their DR progression differs