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However, their use may cause gastrointestinal side effects, especially nausea, which is dose-related and may be prevented by slow dose escalation [6]

Pancreatic ductal adenocarcinoma (PDAC) is another example where TDEs regulate various aspects of tumor behavior, including angiogenesis (miR-27a, VEGFC), cancer-associated thrombosis (TF, ANXA1), immune evasion (H2AF, PKM2), stromal reprogramming, chemoresistance, metastasis, and tumor growth (miR-27a, mir-194-5p, ANXA1, miR-222) through the delivery of specific cargo [32]

doi:10.1530/JOE-15-0284 129

Similarly, peptides must pass quality checks before theyre ready to use

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