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This might explain the common x axis intercept in LineweaverBurk plots 11,17,18 , which resemble a non-competitive inhibition pattern with identical dissociation constants for the inhibitor and substrate 52

The published data showed reductions in glucose and insulin responses by approximately 40% in some measurements

Blood Cells Mol Dis

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The NH of the sulfonamide binds to Glu 431 och Glu 295 via a water molecule bridge