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A diet that is rich in lean proteins, whole grains, and plenty of fruit and vegetable is very effective in managing sciatica pain

doi:10.1111/j.2040-1124.2010.00022.x 4

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Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)