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The GLP-1 receptor activation also reduces appetite and food intake through central nervous system pathways, contributing to significant weight loss observed in clinical trials
The latter effect has been linked to an increase in expression of the pregnane X receptor and the constitutive androstane receptor (Chan et al
The discovery of novel GLP-1 R agonists, which include orally bioavailable agonists, allosteric modulators, and multi-agonists, is noted in this review
doi: 10.1152/ajpcell.00139.2004 56 Vander HeidenMGCantleyLCThompsonCB
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