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c , Overlay of the 2D 1 H- 15 N HSQC spectra of 50 M 15 N-labeled K18 C291A (left) and K18 C322A (right) in the presence of 50 M DA 2 nM mTYR with the incubation time of 1 (pink), 3 (orange) and 5 h (blue), respectively

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All mice were euthanized at 56 days after treatment, tracheal cannulated and lavaged three times with 0.5 ml of sterile cold phosphate-bufered saline (PBS) to collect the bronchoalveolar lavage fluid (BALF)

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