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Multiple safety and research bodies have weighed in: World Health Organization (WHO) : In June 2025, WHO issued a medical product alert highlighting NAION as a potential risk associated with semaglutide (Ozempic, Rybelsus, Wegovy)

162,163 For individuals with obesity, it is unclear whether these goals should be based on actual body weight, corrected (adjusted or ideal) body weight, or fat-free mass, as the use of actual weight can significantly overestimate protein requirements

Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study

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access should be sought only through approved clinical trials