GLP-Pre and GLP-Pro: - Take once daily with a glass of water, preferably with a meal
Retatrutide TRIUMPH-1 (2023) and TRIUMPH-2 (2024) TRIUMPH-1 (Jastreboff et al., NEJM 2023): 338 non-diabetic adults with obesity, 48 weeks at escalating doses: 12 mg dose: 24.2% weight loss 8 mg dose: 22.8% 4 mg dose: 17.5% Placebo: 2.1% TRIUMPH-2 (Rosenstock et al., Lancet 2024) confirmed effects in T2D patients with concurrent NAFLD improvement (hepatic fat reduction 54% at 24 weeks, 12 mg dose)
Some practical considerations: Evening injection some patients prefer injecting in the evening so they can sleep through any initial side effects like nausea Consistency matters most choosing the same day and roughly the same time each week helps maintain stable drug levels Injection sites abdomen, thigh, or upper arm, with rotation between sites to reduce injection-site reactions What about non-standard intervals (every 5 days)
If we want to know how to best use GLPs it is important to think about how we, as a society and as individuals, ended up in an obesity epidemic
Clinical Efficacy and Benefits In clinical trials, Retatrutide has demonstrated substantial weight loss outcomes
A Clear Distinction from Fad Diets What makes semaglutide different from typical weight loss solutions is that it doesnt rely on willpower or unrealistic calorie restrictions
