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We hypothesized that these overlapping mechanisms could benefit people with sickle cell disease. The researchers used TriNetX a global health research network that aggregates deidentified data from more than 275 million patients to identify more than 238,000 people treated for sickle cell disease between 2005 and 2022

These samples assisted in identifying baseline FOXO4 expression patterns and age-related changes in Leydig cells, with all procedures strictly adhering to ethical guidelines and informed consent protocols [2]

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