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Summary Keywords thiamine, gastrointestinal beriberi, acetylcholine, intestinal ThDP-dependent enzymes, intestinal transport of thiamine, intestinal metabolism of thiamine, functional gastrointestinal disorder Citation Overton E, Emelyanova A and Bunik VI (2025) Thiamine, gastrointestinal beriberi and acetylcholine signaling

Pediatr Res 43:435441

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It may, however, act as a useful bridge in specific circumstances: Recovery from illness or jet lag replenishing nutrients depleted by fever, reduced appetite, or long-haul travel Athletes in heavy training blocks supporting recovery when dietary intake may not keep pace with physiological demand Periods of acute stress and poor eating when B vitamin and magnesium turnover is elevated but intake is low Unexplained fatigue with normal bloodwork when standard panels show nothing actionable but the "flat battery" feeling persists Migraine sufferers particularly those with a known or suspected magnesium component to their episodes Those with compromised gut absorption including people on medications that impair nutrient absorption or those with gastrointestinal conditions If you have a chronic health condition, are pregnant, or are taking prescription medications, consult a licensed doctor before proceeding with any IV therapy

After all, your gut is a delicate ecosystem

doi: 10.3389/fimmu.2024.1482386, 49 HuW.ChenM.LinY.ZhangH.SunL.ShaoW.et al