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Sustained carbohydrate intake and observation may be necessary because hypoglycemia may recur after apparent clinical recovery

Importantly, silencing EP300 or inhibiting its activity with C646 (P300/CBP inhibitor) effectively abolished these pathological lactylation events and reversed vascular remodeling traits in PH

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Conversely, some Firmicutes, including butyrate-producing species like Faecalibacterium, Roseburia, and Eubacterium, are known to enhance the function of enteroendocrine cells and maintain barrier integrity, which in turn has an indirect effect on GLP-1 secretion and neuroendocrine activity [130,131]

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