Semaglutide is a GLP-1 receptor agonist, meaning it mimics a hormone the body naturally produces after eating to signal fullness and reduce appetite
lifestyle tweaks are the remedy
Patients with high-risk genetic profiles benefit most from long-term tirzepatide continuation or alternative compounds that address their specific peptide sensitivities
Patients should request a medical review if their weight has remained stable for 4-8 weeks or longer despite adherence to lifestyle modifications and medication
10.1016/j.biopha.2023.115138 60 Hasan AliO.BernerF.AckermannC
Because synthetic GLP-1 doesn't break down as easily as the real thing, it can "help create the feeling that you just ate dinner, so you don't want more food," according to Weill Cornell Medicine obesity expert Louis Aronne, MD, whose most recent research on the drugs appeared in the Journal of the American Medical Association in November 2024