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Superpotent -Melanotropin Analogs: Biological Activities and Melanogenesis in Murine Melanoma Cells Molecular and Cellular Endocrinology Original characterization of Melanotan II demonstrating 100-1000x greater melanotropic potency than native -MSH, prolonged biological activity, and high resistance to enzymatic degradation

This angiogenic effect appears to work through the upregulation of vascular endothelial growth factor (VEGF) and other growth factors critical for tissue repair

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They noted that the indicators used largely reflect more severe outcomes such as hospital care or prolonged sickness absence