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In addition to intracellular effects, itaconate is secreted from activated macrophages, particularly within the tumor microenvironment, where it exerts numerous additional effects

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Recent neuropathological, imaging, and clinical evidence supports the concept of body-first and brain-first PD subtypes, which differ in the initial site and progression of -syn pathology (Fig

Panobinostat is a drug registered in the EU since 2015 for the treatment of relapsed/refractory multiple myeloma [109]

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