However, the profound weight loss observed with GLP-1 RA treatment (as well as other approaches resulting in weight loss through appetite suppression, such as bariatric surgery) raises some concerns
Contraindications that block a prescription
Semaglutide may be right for you if: Youve struggled with weight loss in the past You have a BMI over 25 or are classified as overweight or obese You want a medically guided alternative to crash diets Youre ready to lose weight without extreme restrictions Youre committed to lifestyle changes but want extra support A consultation is required before starting therapy to ensure its safe and appropriate for you
23 Elevation of free T 4 and free T 3 in conjunction with TSH suppression is diagnostic of thyrotoxicosis
Genetic factors influence GLP-1 receptor responsiveness, though routine genetic testing for these variants is not standard practice
In DCCT, participants were randomised to either intensive or conventional insulin therapy (achieving a median HbA 1c level of 7% vs 9% [53 vs 75 mmol/mol], respectively) and followed for a mean of 6.5 years
