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The mechanism of GLP-1-induced nausea involves central GLP-1R activation in the brainstem, specifically in the area postrema, which is the chemoreceptor trigger zone for vomiting

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Microdosing typically refers to using a medication at a dose significantly lower than standard, often below the initial starting dose or maintained long term at the lowest therapeutic level

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The major proglucagon fragment: an abundant islet protein and secretory product