Patients were treated for 80 days with ALA (600 mg/day, treatment group) or with a placebo (control group)
A pivotal safety analysis of the STEP trials found that the overall safety profile is well-characterized and serious adverse events are rare (Wilding et al., New England Journal of Medicine , 2021)
Nauck MA, Heimesaat MM, Behle K, Holst JJ, Nauck MS, Ritzel R, Hfner M, Schmiegel WH: Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
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Since its FDA approval in 2021, semaglutide has emerged as a highly effective, safe option for weight loss