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The FDA requires a CVOT for all antidiabetic agents per its 2008 guidance, and a GLP-1-class CVOT is standard for obesity agents following SELECT (semaglutide 2.4 mg, N=17,604) which showed a 20% reduction in MACE [11]

By integrating physical principles with biological knowledge, this field not only advances our understanding of brain function but also drives the development of innovative neuromodulation techniques

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This conversation should occur at tirzepatide initiation and revisited during dose escalations, as manufacturer guidance recommends backup contraception during these periods

In the UTHealth materials, Dr