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Neuron, 89 (4), 695-710

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however, several challenges still remain, especially the higher cost of a combined therapy and the worldwide underuse of either GLP-1RAs or SGLT2is in clinical practice, even in patients at high cardiorenal risk

Alternatively, increase SubQ injection frequency rather than changing routes: twice-daily SubQ dosing maintains more stable plasma levels than once-daily IM without the tolerability issues