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doi: 10.1371/journal.pone.0100777 155 KeQShiCLvYWangLLuoJJiangLet al

As the main integrator of neural and hormonal signaling, it exhibits circadian oscillations in both hormone secretion and regulatory activity

Additionally, it suppresses appetite, which can lead to significant weight loss

For persistent symptoms, treatment options include: Alginate preparations (such as Gaviscon) that form a protective barrier on top of stomach contents H2-receptor antagonists (such as ranitidine) that reduce acid production Proton pump inhibitors (PPIs) such as omeprazole or lansoprazole for more significant acid suppression NICE guidance supports a 48 week trial of PPIs for reflux symptoms, with periodic review for long-term use

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Step 6: Avoid Rapid Lifestyle Changes Trying to change everything at once can feel overwhelming